What is the difference between Single Ended and differential inputs?
Single-Ended inputs are one-wire inputs connected to the system ground
When acquiring analog signals in the single-ended mode, interfering signals are acquired with the signal. Therefore this mode is only advisable in case of high voltage levels and short lines.
Differential inputs are Two-wire inputs
Interference signals affecting both lines are not included in the measurement because of the difference on the input. This is the optimal mode for measurement lines with a lot of interferences and long lines.